On the contrary, a non-small cell lung cancer cell line H1975-derived xenograft expressing mutant (L858R & T790M double mutation that renders EGFR constitutively active and resistant to erlotinib/gefitinib32) demonstrated constitutive EGFR activation that is independent of regulation by the tumour cell:macrophage proximity (Supplementary Figure S13). Here, EGFR is linked to neoplasm.