MET and hepatocellular carcinoma: Interestingly, AAV serotype 3, which has been shown to have weak tropism for liver (Zincarelli et al., 2008; Cheng et al., 2012), exhibited strong tropism for HCC cells (Cheng et al., 2012) due in part to hepatocyte growth factor receptor (HGFR), a co-receptor for AAV3 (Ling et al., 2010), being overexpressed on HCC (Luo et al., 1999; Cheng et al., 2012).