AVPR2 and hepatocellular carcinoma: More recently, we have integrated drug target prediction, network analysis and experimental validation to find that another herbal pair of Euphorbia kansui (GS) and GC may exert synergistic or antagonistic effects on HCC ascites under different combination designs, partially through regulating the Adrb1-Pik3cg-Avpr2 signal axis21, highlighting the efficiency of network-based approaches to the pharmacological research of herb pairs.