Considering that genetic variants may either have a direct or an indirect (e.g., via altering DNA methylation patterns) influence on disease risk, we further analyzed the effects of 13 SNPs around HTR2B cg27531267 (50 kb up- or downstream of cg27531267) and the interaction of these SNPs with HTR2B cg27531267 on the susceptibility to AD-ND codependence. The gene discussed is HTR2B; the disease is Alzheimer disease.