Previous reports indicate that NF-κB transcriptional activation leads to increased releases of several inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β in Kupffer cells as observed in non-alcoholic steatohepatitis (NASH) livers [6,7,8,9]. The gene discussed is TNF; the disease is metabolic dysfunction-associated steatohepatitis.