EPHB4 and neoplasm: Figure 1A,C shows a typical example of a Stage III patient with high EphA2 and EphB4 staining in the tumor and low staining in normal mucosa. Figure 1B presents a particular case in which normal tissue showed more EphA2 staining than the corresponding Stage III tumor. For EphA2, the mean score for the tumors (4.3 ± 1.8) was significantly higher (p < 0.001) compared with the corresponding normal tissue (3.3 ± 2.3). For EphB4, the difference between tumor and normal mucosa was even more pronounced, with scores of respectively 4.6 ± 1.6 versus 2.3 ± 1.9 (p < 0.001).