Aβ itself can inhibit insulin signaling pathways leading to the dysfunction of downstream pathways (PI3-K/Akt, MAPK, and Wnt) [12,13,14] and a variety of characteristic pathological changes in AD, including accumulation of Aβ, tau protein hyperphosphorylation, and neuronal apoptosis [15,16]. Here, INS is linked to Alzheimer disease.