BCL2 and Alzheimer disease: Furthermore, the relative ratio of Bcl-2/Bax is significantly decreased (p < 0.01) in the PC12 cells treated with Aβ25–35 compared to that of PC12 cells without Aβ25–35 (vehicle) treatment, however, LSS partially or completely revived the decrease induced by Aβ25–35 in a concentration-dependent manner (Figure 7D).These results indicate that the anti-AD effect of LSS may be associated with the protein expressions of Bax and Bcl-2 and it may be the possible mechanism for apoptosis inhibition.