In the clinic, sepsis is usually accompanied by SIRS, which is characterised by over-expression of inflammatory cytokines (IL-6, TNF-α, IL-1β, IFN-γ, etc.)and anti-inflammatory cytokines (IL-10, TGF-β and IL-1Ra)40, 41 and subsequent dysfunction of various organs7, 42. This evidence concerns the gene IL1B and systemic inflammatory response syndrome.