Mechanistically, besides blocking Akt, perifosine has been found to exert its anti-tumor growth effect through inhibition of MAPK pathway17, reduction of telomerase activity and shortening of telomeres13, induction of reactive oxygen species (ROS) production and phosphorylation of JNK and P3818 and inhibition of phosphatidylcholine (PC) synthesis19. The gene discussed is AKT1; the disease is neoplasm.