TFEB is indeed a central hub controlling lysosome-based cellular clearance8, whose potential therapeutic relevance has been demonstrated in models of the major neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and Huntington’s disease through proof-of-principle studies based on heterologous expression of TFEB8, 13, 14, 15, 16, 17. The gene discussed is TFEB; the disease is early-onset autosomal dominant Alzheimer disease.