Pretreatment with CPEE (100 and 200 mg/kg) and AF (9, 18 and 36 mg/kg) significantly (p < 0.05) ameliorated the 3-NP induced alteration in MDA, nitrite, catalase, SOD and GSH levels in the striatum and cortex parts of the brain in comparison to only 3-NP treated animals. This evidence concerns the gene CAT and atrial fibrillation.