Chronic exposure of HCC cells to sorafenib activates Akt, resulting in upregulation and/or activation of its downstream factors including ribosomal protein S6 kinase (S6K) and eukaryotic translation initiation factor 4E‐binding protein 1 (4EBP1) (He et al., 2015; Zhai et al., 2014). The gene discussed is AKT1; the disease is hepatocellular carcinoma.