Phosphatidylinositol 3‐kinase (PI3K), a downstream molecule of c‐Met and an upstream factor for Akt, is shown to be involved in sorafenib resistance of HCC (Ohta et al., 2015; Serova et al., 2013; Zhang et al., 2016), indicating that c‐Met may also regulate Akt activation through PI3K, but it needs further investigation. Here, AKT1 is linked to hepatocellular carcinoma.