Moreover, we also showed that CUL4B was a direct target of miR‐194 and CUL4B could epigenetically repress expression of miR‐194 by monoubiquitination of H2AK119 and trimethylation of lysine 27 on histone 3 on the miR‐194 promoter, thus creating a double‐negative feedback loop between miR‐194 and CRL4B in lung cancer tumorigenesis. This evidence concerns the gene CUL4B and lung carcinoma.