BRCA1 and breast carcinoma: Recent integrated analyses of messenger RNA expression, microRNA expression, DNA methylation and DNA copy number aberrations have shown that more than 30% of high-grade serous ovarian carcinomas and basal-like breast cancers had a dysfunctional BRCA pathway as a consequence of germline or somatic BRCA1/2 mutations or BRCA1 promoter hyper methylation [5].