In order to ascertain damaging role of ICAM-1 in type 2 diabetic nephropathy, Chow et al. [266] evaluated the development of renal injury in both ICAM-1 intact and deficient db/db mice with similar glucose level and obesity and found that ICAM-1 deficient db/db mice showed significantly attenuated glomerular hypertrophy and renal fibrosis accompanied by reduced glomerular and interstitial infiltration of macrophages. The gene discussed is ICAM1; the disease is obesity due to melanocortin 4 receptor deficiency.