Similarly, Okada et al. [267] showed that ICAM-1 knock-out mice have been able to prevent the progression of albuminuria, glomerular infiltration of macrophages, glomerular hypertrophy, and interstitial fibrosis at 6 months after the induction of diabetes mellitus, whereas ICAM-1+/+ demonstrated the opposite outcome. This evidence concerns the gene ICAM1 and diabetes mellitus.