Recently, sulodexide, a compound made up of heparan and dermatan sulfate types of GAGs, has suppressed podocyte-specific VEGF synthesis through inhibition of high glucose-induced p38-MAPK in OLETE rats, a type 2 diabetic animal model, and it has elicited all aforementioned anti-VEGF agent-mediated renoprotective effects including decreased urinary albumin excretion and expression of profibrotic molecules [247]. The gene discussed is VEGFA; the disease is type 2 diabetes mellitus.