AGT and cardiac hypertrophy: Previous studies have found that the apoptosis of myocardial cells plays certain role in the process of pathological cardiac hypertrophy probably because of the existence of negative feedback regulation in the process of tissue proliferation and apoptosis while the increase of levels of AngII and other tissue factors can stimulate the synthesis of proteins related to activating the apoptosis genes leading to promoting the apoptosis of myocardial cells and further decreasing myocardial contraction force and deficient pump blood [13, 14].