Our results indicate that the absence or presence of the TLR2 receptor did not interfere with fungal clearance in healthy mice; however, the absence of TLR2 was favorable for mounting an early granulomatous response, as demonstrated by the increased number of epithelioid macrophages in TLR2−/− mice, which is indicative of a typical Th1 response and efficient immune clearance of dermatophytosis. This evidence concerns the gene TLR2 and dermatophytosis.