Our study has some limitations; for instance, we did not determine the Tm ligands specific to TLR2 and mechanistic explanations on the role of TLR2 signaling in antigen presentation, phagosome maturation and the development of adaptive immunity; however, our results show, for the first time, the influence of TLR2 in the outcome of experimental dermatophytosis and its impact in the context of a diabetes model during fungal infection. The gene discussed is TLR2; the disease is dermatophytosis.