Some studies indicate that GluN2A-containing NMDARs are important for synaptic plasticity [100, 101], and their functions are reduced in certain brain diseases such as schizophrenia, while excessive activation of GluN2B-NMDARs may trigger excitotoxicity in such conditions as stroke/ischemia and Alzheimer's diseases [102–105]. This evidence concerns the gene GRIN2A and schizophrenia.