In addition, double knockout of TNFα receptor 1 and 2 protects mice against liver lipid accumulation and other features of NAFLD induced by consumption of a methionine/choline-deficient diet [38], whereas anti-TNFα antibody treatment was shown to decrease lipid content and JNK signaling pathway in HFD-fed ob/ob mice [39]. Here, MAPK8 is linked to metabolic dysfunction-associated steatotic liver disease.