Indeed, it was recently demonstrated that HSCs are primary responders to infections as they are directly targeted by MAMPs and multiple inflammatory cytokines, such as IFNα, IFNγ, IL-1, interleukin-6 (IL-6), or TNFα, which distinctively affect their cycling properties, differentiation, repopulating activity, and migration patters (5, 16, 17, 19). This evidence concerns the gene IL6 and infection.