Matthay et al. (2012) described three successful therapeutic targets for neuroblastoma that are in practice today: (1) hNET targeted by radiotherapy via 131I-metaiodobenzylguanidine (MIBG) (2) the GD2 ganglioside targeted by monoclonal antibodies, and (3) ALK targeted by kinase inhibitors. The gene discussed is ALK; the disease is neuroblastoma.