BSG and neuroblastoma: However, it is worth mentioning two categories of excellent protein targets in neuroblastoma that are beyond the scope of homology modeling: first, proteins which have known crystal structures such as CD147, which is associated with decreased neuroblastoma differentiation (Garcia et al., 2009; Wright et al., 2014), and CD57, which has also been implicated in aggression of neuroblastoma (Kakuda et al., 2004; Schlitter et al., 2012).