15 differential expressed genes existed steady difference, Bcl2, VEGFA, PTEN, Jun, Fos, APC2 were up-regulated and Ccna2, Cdc25a, Mcm3, Mcm6, Ccnb2, Mcm5, Cdk1, Gadd45a, Myc were down-regulated in MMQ tumor stem-like cells group (P < 0.05, Fig. 1e). This evidence concerns the gene MCM5 and neoplasm.