The authors investigated VEGFR2, PDGFR-α, and PDGFR-β tyrosine-kinase (TK) domain for genetic variants both in CRC cell lines and in CRC samples of 92 patients; four genetic variants were identified and the G-allele genotype of PDGFR-β exon 19 SNP (rs246395) was frequently found (58%) in CRC specimens, also being correlated with increased PDGF pathway activation and poor survival. Here, TKT is linked to colorectal carcinoma.