PDGFB and cancer: The discovery that PDGF-B has a homology structure with simian sarcoma virus oncogene (v-sis) and because of its Ras/MAP-kinase signaling that led to transcription of target genes with role in cell survival, proliferation, invasion, and metastasis made PDGF-B to be considered an important oncogene with role in cancer development by PDGF/PDGFR signaling pathways [50].