Following description of a succinate dehydrogenase type B (SDHB) mutation positive patient with a pituitary adenoma [66] and SDHB mutation positive familial PGLs and macroprolactinomas [67], somatotroph adenomas have also been associated with SDH mutations (SDHA, SDHB and SDHD) [64, 65, 68, 69]. This evidence concerns the gene SDHB and growth hormone-secreting pituitary adenoma.