KCNJ5 and secondary hypertension: In individual patients in whom clinical investigation indicates secondary hypertension, sequencing analysis has repeatedly identified new genetic variants and new mechanisms of blood pressure regulation, including KCNJ5 mutations associated with adrenal hyperplasia and mutations of CACNA1D encoding a voltage-gated calcium channel causing cause adrenal aldosterone-producing adenomas in the absence of KCNJ5 mutations.15, 16