INS and obesity due to melanocortin 4 receptor deficiency: To confirm the above reported findings, we examined the association of rs7566605 polymorphism with obesity defined by BMI and obesity-associated phenotypes; particularly with systolic blood pressure, diastolic blood pressure, serum concentrations of glucose, insulin, and with a surrogate measure of insulin resistance, i.e. the homeostasis model assessment (HOMA) index of insulin resistance.