Western blot results verified that miR-320a transfection significantly decreased MMP2 and MMP7 proteins (P<0.05~0.001) through inhibiting SND1 or β-catenin expression (P<0.05~0.01) in GBM cells, and the suppressive effects of miR-320a could be reversed by SND1 or β-catenin overexpression (P<0.05~0.001; Figure 5E and 5F). The gene discussed is MMP2; the disease is glioblastoma.