These facts indicated that miR-320a was a glioma suppressor, and suggested that SND1 and β-catenin overexpressions induced by miR-320a downexpression were important causes leading to the unlimited proliferation, migration and invasion of malignant glioma cells, highlighting the potential values of miR-320a, SND1 and β-catenin in the therapy of malignant gliomas. This evidence concerns the gene SND1 and glioma.