Furthermore, miR-320a transfection reduced cyclin D1 and increased p21WAF1 (P<0.01) by decreasing β-catenin or SND1 (P<0.05~0.01) in GBM cells, which could also be reversed by β-catenin or SND1 overexpression (P<0.05~0.01; Figure 4F and 4G). This evidence concerns the gene CCND1 and glioblastoma.