Subsequently, we confirmed that miR-320a-induced knockdowns of SND1 and β-catenin significantly increased p21WAF1 or decreased cyclin D1, and reduced the expressions and extracellular activities of MMP2 and MMP7 of GBM cells, consequently suppressing their G1/S phase transition, proliferation, migration and invasion. Here, CCND1 is linked to glioblastoma.