We then detected SND1 and β-catenin in the above FFPE specimens of gliomas and brain tissues by IHC, and found that SND1 and β-catenin expressions were higher in gliomas than in brain tissues and were significantly increased with the elevation of glioma grades (P<0.001; Figure 3A and 3B). The gene discussed is SND1; the disease is glioma.