To investigate the underlying mechanisms by which miR-320a suppresses glioma cell proliferation, U87MG and U251 cells were alone transfected with Scr or miR-320a mimics and co-transfected with miR-320a mimics plus the plasmid expressing β-catenin (miR-320a+ CTNNB1) or SND1 (miR-320a+SND1). This evidence concerns the gene SND1 and central nervous system cancer.