These results indicate that SND1 promotes MMP2 expression as a signaling amplifier of TGFβ1 pathway, and that miR-320a restrains the MMP2 overexpression induced by TGFβ1 pathway overactivation via directly silencing SND1, thereby inhibiting the migration and invasion of GBM cells (Figure 6E). This evidence concerns the gene MMP2 and glioblastoma.