More importantly, PD153035 treatment alone inhibited the basal level of CLDN3 in ADC cells that did not receive EGF treatment, suggesting that EGFR signaling pathway activation is potential required for the maintenance of CLDN3 expression (Figure 5B &5C, compared with control cells, **p<0.01; compared with EGF-treated cells, ##p<0.01). Here, CLDN3 is linked to AIDS dementia complex.