To evaluate the prognostic significance of the serum chemerin levels, we used serum chemerin cut-off value 1500 pg/ml, which was calculated from previous ROC analysis, as a threshold to partitioned 189 NSCLC patients into two groups, high serum chemerin group (chemerin ≥ 1500 pg/ml, n = 118) and low serum chemerin group (chemerin < 1500 pg/ml, n = 71). This evidence concerns the gene RARRES2 and non-small cell lung carcinoma.