DPP4 and diabetes mellitus: Similarly, the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR-TIMI 53) trial showed that saxagliptin-mediated preservation of β-cell function was better in patients with higher homeostatic model assessment 2 (HOMA2) scores prior to DPP-4 inhibitor treatment [17].