Overall, MI‐2‐2 showed significantly higher cellular activity with 80% reduction of HoxA9 and Meis‐1 expression at 6 μM and exhibited significant effect in human leukemia cell line MV4;11 carrying the MLL1–AF4 translocation, which is consistent with the improved potency towards the Menin–MLL1 interaction.111 He and colleagues112 also identified hydroxy‐ and aminomethylpiperidines as inhibitors of the Menin–MLL1 interaction through screening a library of 288,000 compounds by FP. The gene discussed is MEN1; the disease is leukemia.