Unsupervised clustering analysis of the HLA-A*02:01-restricted HM immunopeptidomes (AML (n=9), CML (n=6), CLL (n=16), MM/MCL (n=4/1)) resulted in clear clustering of samples belonging to the same hematological cancer entities, as well as coherent clustering of the lineages these malignancies arise from (Figure 2A). Here, HLA-A is linked to hematopoietic and lymphoid cell neoplasm.