In this context our study documents besides anti-neoplastic efficacy of the standard chemotherapeutic Etoposide in MYC-amplified as well as SHH-TP53-mutated medulloblastoma cell lines an additive anti-tumorigenic efficacy for the Etoposide-Vandetanib combination in comparison to single drug application (Figure 7). Here, TP53 is linked to medulloblastoma.