Mice lacking PEMT were already protected against diet-induced obesity and glucose intolerance, and fenofibrate did not have an additive effect on these parameters (Fig. 3), nor did it change mRNA levels of genes involved in glucose metabolism in liver or brown adipose tissue in Pemt−/− mice (supplemental Fig. S1A, B). The gene discussed is PEMT; the disease is obesity due to melanocortin 4 receptor deficiency.