IL6 and Hyponatremia: For 1 thing, hospital‐acquired lower serum sodium is found to coincide with various inflammatory conditions.24, 25 Inflammatory cytokines such as IL‐1β and IL‐6 have been reported as mediators in the development of hyponatremia related to ADH secretion.25, 26, 27 Inflammation is associated with impaired renal function.