CARD9 and obesity due to melanocortin 4 receptor deficiency: Additionally, zinc supplementation will inhibit Bcl10/CARD9‐mediated p38 MAPK activation whereas zinc deficiency will further activate the pathway; (2) obesity‐induced expression of Bcl10/CARD9 is mediated by increased oxidative stress, which can be enhanced by zinc deficiency or ameliorated by zinc supplement; and (3) the prevention of obesity‐induced oxidative stress and subsequently up‐regulation of Bcl10/CARD9 expression by zinc supplement is mediated by up‐regulation of MT as a potent antioxidant.