TARDBP and amyotrophic lateral sclerosis: However, while these studies suggest that the DPR are the likely major toxic insult derived from the sense (G4C2)n RNA, antisense (C4G2)n RNA foci, but not sense (G4C2)n RNA foci, correlate with TDP-43 proteinopathy in motor neurons from C9ORF72-ALS patients (44).