Thus, the negative correlation of TWIST1 (r = -0.54, p < 0.01), LAMB1 (r = -0.58, p < 0.001), and THY1 (r = -0.48, p < 0.01) in low tumor Hp expression groups could be a signature of poor cancer differentiation also the prognostic role of Hp in HCC cancer cell differentiation. The gene discussed is TWIST1; the disease is hepatocellular carcinoma.