To verify our results that lower Hp expression is correlated with poor HCC cancer cell differentiation, we selected several markers (TWIST1, LAMB1, THY1, EZH2, SALL4, and TCF3) that are closely associated with the activation of poor HCC cancer differentiation and analyzed the Pearson correlation coefficient of each selected marker to Hp. The gene discussed is EZH2; the disease is hepatocellular carcinoma.