The mutational landscape of melanoma has been thoroughly examined, and driver mutations in the BRAF, NRAS, KIT, GNAQ, GNA11, NF1, CDKN2A, PTEN and MITF genetic loci have been recurrently recognized [1–4, 8, 11, 12], with BRAF alterations typifying up to ~70% of melanoma tumors [3, 12, 13]. The gene discussed is GNAQ; the disease is melanoma.