Fixed-effects model showed the pooled HR for the OS comparing SETBP1 mutation versus wild-type SETBP1 was 1.808 (95% CI: 1.218–2.685, P = 0.001) (Fig 2), suggesting that SETBP1 mutation may be a factor for the poor prognosis in MDS patients. Here, SETBP1 is linked to myelodysplastic syndrome.