In addition, overexpression of Pea3/ETV4 was shown to result in increased levels of vimentin [9], the intercellular adhesion molecule ICAM-1 [10,11], osteopontin [12], vascular endothelial growth factor and cyclooxygenase-2 [13], thus providing evidence for the importance of PEA3/ETV4 in tumor formation and metastasis. This evidence concerns the gene ETV4 and neoplasm.