MAPT and supranuclear palsy, progressive, 1: Progressive supranuclear palsy (PSP) represents the most common form of atypical Parkinsonism[1], with a prevalence of 6.5 cases/1.000.000 people.[2] The neuropathological hallmark of PSP is a biochemical alteration in the tau protein, which results in a neurodegeneration and gliosis in the basal ganglia, brainstem, prefrontal cortex and cerebellum.[3]