A significant elevation in Lrrc2 mRNA was observed in neonatal rat ventricular myocytes following treatment with endothelin-1 as well as in the myocardium of mice and rats following thoracic aortic constriction (TAC)-induced cardiac hypertrophy, indicating a potential role in maladaptive hypertrophic remodelling (Fig 4A). This evidence concerns the gene EDN1 and cardiac hypertrophy.