AKT1 and posterior cortical atrophy: In addition to these three pathways, genes that were down-regulated only in MDA-PCa-2b cells by miR-24 transfection, were significantly enriched in the PI3K-Akt and AR Signaling Pathways (p = 2.79E-05 and p = 8.73E-05) (Supplementary Table 3) in agreement with the results of our calculations.