In fact, in our previous work, we stated that combination therapy either with anti-Notch/anti-EGFR or anti-EGFR/anti-PDGFR drugs compared to therapy alone was more effective in reducing survival of c-CSC compared to p-CSC, suggesting that in the area of GBM peritumor tissue occurs a selection process, which results a more aggressive cell phenotype [17, 18]. This evidence concerns the gene EGFR and glioblastoma.