In line with this, in the current study we reported a significant down-modulation of mesenchymal genes FN1, VIM1 and TWIST1 that positively correlated to the inactivation of Notch1 and Stat3 signaling pathways in shHes1-CSC, suggesting further the primary role played by the association of Stat3 and Notch1 in mesenchymal GBM [5–8]. The gene discussed is TWIST1; the disease is glioblastoma.