BRAF and colonic neoplasm: Our in-vitro assays confirmed that BRAF and MEK were inhibited by MBZ in the nM range (Figure 1C), with MBZ inhibiting both BRAFV600E and BRAFWT with a Kd of 210 and 230 nM, respectively, in agreement with previous results with a kinase screen of MBZ, chosen for its ability to inhibit colon cancer growth [13].