CASP3 and neoplasm: Western blot analysis showed that anti-apoptotic proteins (Bcl-2 and Bcl-xl) exhibited similar reductions, which were accompanied by increases in the levels of pro-apoptotic proteins (Bax and cleaved caspase-3) (Figure 2B), suggesting that the induction of apoptosis is one of the major anti-tumor mechanisms of FM807 in CNE1 and CNE2 cells.