Whether size > 10 mm is one well established definition criterion of advanced neoplasia, association with EGFR overexpression was not confirmed in this study by multivariate analysis (p = 0.67), in contrast with other co-factors such as HGD (OR: 1.98 [1.64–2.40]; p < 0.0001) and tubulovillous or villous feature (OR: 2.31 [1.77–3.01], p < 0.0001). Here, EGFR is linked to neoplasm.