The serum levels of AFP in HCC patients decreased dramatically after tumor tissue resection (median [IQR], 246.00 [62.52–845.80] ng/ml vs. 5.24 [2.14–20.10]) ng/ml (P < 0.0001), while the serum levels of GP73 remained stable (median [IQR], 96.53 [61.47–150.20] ng/ml vs. 93.38 [61.61–136.70]) ng/ml (P = 0.397) (Figure 4). The gene discussed is GOLM1; the disease is hepatocellular carcinoma.