As shown in Figure 3A, though a 0.834 (95% CI: 0.816–0.850, P < 0.0001) area under the ROC curve for GP73 made it able to distinguish HCC patients from those pre-cirrhotic CLD patients, it dropped to 0.613 (95% CI: 0.595–0.630, P < 0.0001) when cirrhotic patients were used as non-HCC control (Figure 3B). The gene discussed is GOLM1; the disease is congenital secretory chloride diarrhea 1.