HSPA5 and cancer: These results showed that three types of cancer cells treated with 10 nM siRNA for 48 h could lead to approximately 50% repression of GRP78 expression compared to control (Figure 5A, 5D and 6A), and the expression of LC3 were significantly decreased in the three types of cancer cell lines depleted of GRP78 cells (Figure 5B, 5C, 5E, 5F, 6B and 6C).